Program active ingredient

Manufacturers of drug products, dietary supplements or foods need to ensure the quality of raw materials used in their manufacturing processes. Supplier qualification plays a key role in providing this assurance. Ingredient and product manufacturers can help bolster supply chain control confidence in finished goods through a rigorous third-party quality evaluation program to reduce the risk of inconsistent and substandard ingredient quality, strengthen confidence that Good Manufacturing Practices GMP and science-based quality standards have been implemented and are being met, and reduce supplier qualification burden by decreasing the number of customer audits.

Read the article. Excipient Ingredient Verification Program Get an overview of the program, download the participant manual, fill out the application form and see company participants. Pilot project participants included authorizers and schools.

Five different charter authorizing institutions from around the country participated in the Active Ingredients pilot project. Each authorizer invited schools within their portfolio to participate. The project provided expert coaches to support the selection of appropriate measures and provide guidance on Active Ingredient data collection and reporting.

The authorizer also with the help of an expert coach selected an appropriate method of measuring that Active Ingredient. The authorizers provided guidance to the schools as necessary during the data collection phase, and worked with coaches to document successes and challenges along the way. All participants attended a mid-pilot national convening in February to share progress and learn from each other.

Activities for this project began in spring with planning for pilot implementation. Data collection occurred during the school year, and the final report was completed in October Descriptive data about the participating schools and their programs will be used to describe pilot participants and share how additional Active Ingredients measures were selected and relate to the school program.

De-identified student data will also be collected to investigate the credibility of new data collection and reporting processes. Lastly, reflection data will be collected from participants to make recommendations for future improvement to the framework and processes. The project concluded with an evaluation report and a set of resources and tools other interested schools and authorizers can use to add additional measures of student success.

Yes, Phase 2 of the project will launch in The product comes with a long expiration time - 3 years after manufacture for the feline Program flea control suspension. Lufenuron flea control injection is given 6-monthly to cats. The injection is a subcutaneous injection. Program 40 Injectable Suspension for Cats - each 6-monthly dose contains 40 mg of lufenuron for cats to 4kg weight. The Program flea control injection does not need to be purchased by pet owners.

Your vet can give the injection every 6 months in the vet clinic. The product must be shaken well before use and all used needles should be placed safely into a 'sharps' bin. It takes about weeks for Lufenuron to attain the correct concentration in cats following the injection.

Program flea control injection can not be used in dogs. It is a cat product only. Re-introduced flea populations at weeks 19 and 26 were well controlled, with some control still present in fleas reintroduced at week 36, but not week Program's Lufenuron is a chemical with lipophilic properties, which is another way of saying that it binds well with fat.

When Lufenuron is taken into the body of a dog or cat by oral or injectable means , it becomes attracted to and stored in the fat cells of the animal's body. As the Lufenuron present in the animal's bloodstream depletes either through flea consumption or through other bodily excretion pathways , the drug stored in the fat cells steadily leaches back into the animal's blood stream over time. It takes a good 40 or so days for an oral dose of Lufenuron flea control to be completely expelled from the animal's fat stores and thereby rendered ineffective against fleas.

The flea control effect of Lufenuron is therefore able to continue for the full month between oral doses. With the injectable product, more of the drug enters the body the product is not lost to the feces as much of the oral dose is and so more is taken up into the fat cells, ensuring a longer leeching process and thus a longer duration of effect 6 months.

Dogs and cats over 6 weeks of age can be treated with Program flea treatment i. Program flea control products are registered for use in dogs and cats only. Lufenuron can be given to rabbits, but the use is off-label and can not be in any way guaranteed see your vet for information and doses. Toxicity studies performed on Lufenuron have found the chemical to be toxic to small aquatic organisms e. For this reason, care must be taken to ensure that Lufenuron does not contaminate water supplies.

Toxicity studies have found Lufenuron flea control to be "practically non-toxic to fish, birds and adult bees. Tests on laboratory animals and cell cultures have determined that the chemical, Lufenuron Program flea control does not cause mutations, cancer, fetal malformations or any other reproductive effects.

It should therefore be safe to use in pregnant animals and animals intended for breeding see MSDS publications.

Additionally, even though Lufenuron accumulates within the fat of milk, it has not been found to have any negative effect on nursing puppies and kittens.

Adverse effects are considered to be quite rare with Program flea control medications. Those that occur mostly take on the form of a mild gut upset or an allergic reaction which can happen in individuals with any medication. Known side effects include: vomiting, diarrhea, lethargy sleepiness , depression and itching, redness and rashes of the skin only one or a combination of these may present in the one individual.

Cats may sometimes develop a lump at the site of injection, if having the injectable product. This lump will generally resolve in a couple of weeks. If you accidentally overdose your dog or cat, you should talk to your vet about it. It is important to remember, however, that when the early studies were being done on dogs and cats, they gave some 30x the normal dose of Lufenuron to puppies and some 17x the usual dose to cats and didn't record any significant or long-term effects.

An LD50 is the dose that will kill half of the study population. The MSDS considers Lufenuron to be non-irritant to skin or eyes rabbit studies and of low toxicity when given orally, inhaled or applied dermally. Guinea pig studies found that it was non-sensitising i. Discarded needles should always be safely disposed of in a designated "sharps" container. Animals with flea allergy dermatitis are allergically sensitized to fleas such that they have a severe skin reaction itching, scratching, rashing each time a flea bites them.

In such animals, the immune system is reacting inappropriately and extremely to elements antigens that are present in the flea's saliva. It can take a single flea bite to set a flea allergic animal off on a path of scratching you might not even see any fleas on the animal - the flea has simply jumped on, bitten and then jumped off again, leaving the animal to itch away.

The issue with Program flea control Lufenuron is that it relies on the adult fleas feeding in order to exert its effect on the next generation of fleas. It will not kill the adult fleas and, more importantly, it will not reduce or limit adult flea feeding times which is where allergic sensitization occurs - when the animal is exposed to the flea's saliva.

Thus, it will not go a huge way towards helping cure flea allergic dermatitis at least in the first few months when adult fleas are still about and feeding off the allergic pet - see next paragraph. With no fleas about, the animal with flea allergic dermatitis will improve and perhaps even resolve significantly.

Dogs and cats in a flea-introduced environment were given Program flea control on a monthly basis and at the doses recommended by the Novartis Company the doses that the Program packet recommends. Program flea control certainly has a role to play in getting rid of flea populations and ending flea allergy reactions, however, during the first few months at least, owners of flea allergic animals should also apply a flea control product that kills adult fleas quickly and reduces their feeding times.

Do be aware, however, that Program flea treatment will not prevent the dog or cat from catching fleas whenever it enters a flea infested environment e. These fleas will leap onto your pet and bite it, starting the scratching all over again. In animals with flea allergy dermatitis, you really want to prevent this flea bite from occurring or at least limit the duration of flea feeding and so you should make sure to put a 'fast-kill' adulticide flea control product on your allergic pet if it is to leave your freshly-cleaned home.

Program flea control product links:. To go from this Program flea treatment page to my detailed Flea Control Page, click here. To go from this Program Lufenuron page to the Flea Pictures page, click here. St Leonards, , Havas MediMedia. Control of Ctenocephalides felis on dogs and cats using the insect growth regulator or chitin synthesis inhibitor lufenuron Program, in Egypt. Mode of action of lufenuron on larval cat fleas Siphonaptera: Pulicidae.