Losartan clinical trials for copd


















Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Acute pulmonary exacerbation within 6 weeks from the Screening Visit. Subjects with no airflow obstruction by spirometry but with a decrease in diffusing capacity of lung for carbon monoxide DLco possibly indicating emphysema. Significant exposure to environmental tobacco smoke or atmospheric or occupational pollutants Urine pregnancy positive test at the Screening Visit.

Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Drug: Losartan 50 mg Drug: Losartan mg. Phase 4. Study Type :. Last Update Posted : October 5, Study Description. Detailed Description:. Losartan is an angiotensin receptor blocking agent, commonly used as an antihypertensive agent, which has been shown to alter cardiac remodeling after myocardial infarction and renovascular remodeling in diabetes-mellitus.

The primary outcome measure will be the rate of progression of emphysema, quantified as the percent of lung voxels with a density less than HU as measured by High Resolution CT HRCT, from baseline to 48 weeks. Drug Information available for: Losartan Losartan potassium. FDA Resources. Arms and Interventions. At randomization participants will start with a dose of one capsule inactive once a day for 2 weeks. Outcome Measures. Primary Outcome Measures : change in mean pct [ Time Frame: 48 weeks ] change in percentage of voxels with density less than Hounsfield Units.

Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Metallic objects in the chest such as shrapnel or pacemaker leads For women of child bearing potential, positive pregnancy test or unwillingness to use two methods of birth control or abstinence for the duration of the study Major chronic illnesses which in the judgment of the study physician would interfere with participation in the study e.

Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. Your message has been sent to the study team at ,. Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate. If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study.

Once enrolled you may be asked to make scheduled visits over a period of time. Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor. Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

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